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PA-8
  • 商城价格 登录后可查看价格
  • 货号 T41005
  • 品牌 TargetMol ( 生产厂家 )
  • CAS号 878437-15-1
  • 规格/包装 5 mg
  • 单位 瓶
  • 储存条件 -20度
  • 现货状态 现货
  • 数量

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PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo.
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