CDN1163产品活性：CDN1163 是一种肌膜/内质网 Ca2+-ATPase (SERCA) 的变构激活剂，可改善 Ca2+ 稳态。CDN1163 可减轻糖尿病和代谢紊乱。产品来源： https://www.medchemexpress.cn/CDN1163.html研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling作用靶点：作用靶点：Calcium ChannelIn Vitro: CDN1163 (10 μM; 24 hours; rat cardiac myocyte cells) treatment reduces high glucose-induced resistin and nuclear NFATc expression and increases the phosphorylation of AMPKα in a time-dependent manner.In Vivo: CDN1163 (50 mg/kg; intraperitoneal injection; for 5 days; male ob/ob mice and lean ob/+ mice) increases SERCA2 Ca2+-ATPase activity, decreases endoplasmic reticulum (ER) stress-induced cell death in vitro and improves liver Ca2+ transport activity. CDN1163 reduces blood glucose levels and improves metabolic parameters and gluconeogenic gene expression, reverses hepatic steatosis, inhibits ER stress and ER stress-induced apoptosis, and improves mitochondrial efficiency in ob/ob mice in vivo.相关产品：Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Reprogramming Compound Library | Diabetes Related Compound Library | Endoplasmic Reticulum Stress Compound Library | Ionomycin | Thapsigargin | L-Ascorbic acid | 2-Aminoethyl diphenylborinate | Ebselen | Verapamil hydrochloride | Acetylcholine chloride | Nifedipine | Fasudil Hydrochloride | GSK1016790A | Tetrandrine | Halofuginone | ISX-9 | Gabapentin | Mibefradil dihydrochloride | Diltiazem hydrochloride | DS16570511 | Istaroxime hydrochloride | L-Phenylalanine | Nimodipine | GSK-7975A | Ethacrynic acid | Flufenamic acid | Amlodipine | TPC2-A1-N | Felodipine | Penfluridol品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。https://www.medchemexpress.cn/CDN1163.html