(Z)-4EGI-1产品活性：(Z)-4EGI-1 是 4EGI-1 的 Z-型异构体，是 eIF4E/eIF4G 相互作用和翻译起始的抑制剂。(Z)-4EGI-1 有效结合 eIF4E ，IC50 为 43.5 μM，Kd 值为 8.74 μM。(Z)-4EGI-1 具有抗癌活性。产品来源： https://www.medchemexpress.cn/z-4egi-1.html研究领域：Cell Cycle/DNA Damage作用靶点：作用靶点：Eukaryotic Initiation Factor (eIF)In Vitro: (Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected.(Z)-4EGI-1 inhibits cancer cells proliferation with IC50 values of 15.3 μM and 11.6 μM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively.相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | GCN2iB | Rocaglamide | GCN2-IN-1 | Silvestrol | 4EGI-1 | Zotatifin | CR-1-31-B | eIF4A3-IN-2 | 4E1RCat | GCN2-IN-6 | eIF4A3-IN-1 | SBI-0640756 | 4E2RCat | Briciclib | 2BAct | ATPγS tetralithium salt | CMLD012612 | CMLD012072 | CMLD012073 | eIF4A3-IN-4 | eIF4A3-IN-5 | eIF4A3-IN-6 | eIF4A3-IN-7 | eIF4E-IN-1 | eIF4E-IN-2 | eIF4E-IN-3品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。https://www.medchemexpress.cn/z-4egi-1.html