disease:Genetic variations in MBL2 are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.,disease:There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections.,function:Binds mannose and N-acetylglucosamine in a calcium-dependent manner. Is capable of host defense against pathogens, by activating the classical complement pathway independently of the antibody.,online information:Mannose-binding protein,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 colla

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