catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,catalytic activity:Retinol + NAD(+) = retinal + NADH.,catalytic activity:Testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH.,function:NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.,similarity:Belongs to

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