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GPX4 24
  • 商城价格 登录后可查看价格
  • 货号 T83780
  • 品牌 TargetMol ( 生产厂家 )
  • CAS号
  • 规格/包装 1 mg
  • 单位 瓶
  • 储存条件 -20度
  • 现货状态 一个半月
  • 数量

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GPX4 24, a derivative of (1S,3R)-RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound effectively induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells with an EC50 value of 0.16 µM. Additionally, at a dose of 200 mg/kg, GPX4 24 elevates malondialdehyde (MDA) levels in both kidney and plasma of mice, highlighting its impact on lipid peroxidation.
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