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CD86 (B7-2) Monoclonal Antibody (IT2.2), APC, eBioscience
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  • 货号 17-0869-42
  • 品牌 Invitrogen ( 经销商 )
  • CAS号
  • 规格/包装 100 Tests
  • 单位 支
  • 储存条件
  • 现货状态 一周
  • 数量

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Description: The IT2.2 monoclonal antibody reacts with human CD86, an ~80 kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.\t
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