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CC1 Guinea pig pAb
Catalog No: OB-PGP027RRID: AB_2938820Host Species: Guinea pigImportant Notice: Antigen retrieval is recommend before IHC/IF-Fr staining.Species Reactivity: Mouse, Rat; Predict to work in primatesApplications: IF/IHC-Fr: 1:200~500 IHC-P: 1:50~200 WB: 1:500~1000
Antigen Retrieval: For an alternative approach, tissue sections could be incubated in 1x Citrate antigen retrieval solution for 30 min at 95°C and cool down to room temperature before next procedure.
Immunogen: Synthetic peptidePurification: Affinity purificationGeneral Notes: FOR RESEARCH USE ONLYStorage Buffer: pH7.4, PBS, 55mM Tris, 50mM Glycine, ~40% Glycerol, 0.1% potassium sorbateStorage: Shipped at 4°C. Store at -20°C/4°C for months and -80°C for years. Avoid freeze/thaw cycle
Background: Few markers exist that specifically label mature oligodendrocyte cell bodies in the central nervous system without labeling myelin. Thus, when staining for oligodendrocytes, the cell bodies typically are masked by the abundant surrounding myelin, making them difficult to identify or precisely count. The monoclonal antibody anti-adenomatous polyposis coli (APC) clone CC1, hereafter referred to as the CC1 antibody, is the most common tool used to specifically detect mature oligodendrocytes without labeling myelin. CC1 is a useful and reliable marker for counting the number of mature oligodendrocytes in postnatal animals (older than P15 in the brain and P7 in the spinal cord). When used in the CNS tissues of neonatal mice, astrocytes and OPCs with weak CC1 expression should be excluded from mature oligodendrocyte population based on their morphology, gene expression level and tissue distribution.
Key Words: oligodendrocytes, mature oligodendrocytes, myelin, myelinating oligodendrocytes
