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The OX-42 antibody reacts with the CR3 complement (C3bi) receptor expressed on
monocytes, granulocytes, macrophages, dendritic cells, and NK cells. This antibody appears
to recognize a common epitope shared between CD11b and CD11c (integrin α and α
chains). The OX-42 antibody precipitates three polypeptides with apparent molecular weights
of 160, 103, and 95 kD, respectively. This antibody has been shown to block the formation of
complement-mediated rosettes and leukocyte migration.