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Cyproheptadine hydrochloride
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  • 货号 HY-B0366A
  • 品牌 MedChemExpress (MCE) ( 经销商 )
  • CAS号
  • 规格/包装 1G
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Cyproheptadine hydrochloride 是一种有效的口服活性 5-HT2A 受体 (5-HT2A receptor) 拮抗剂，具有抗抑郁和抗血清素作用。Cyproheptadine hydrochloride 具有抗血小板活性。Cyproheptadine hydrochloride 可以用于血栓栓塞性疾病的研究。
生物活性

Cyproheptadine hydrochloride is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine hydrochloride has antiplatelet and thromboprotective activities. Cyproheptadine hydrochloride can be used for the research of thromboembolic disorders[1][2].

IC50 & Target[1]

5-HT2A Receptor

5-HT2 Receptor

体外研究
(In Vitro)

Cyproheptadine hydrochloride (0.01-100 nM；1 minute) 在体外剂量依赖性地抑制血清素增强的 ADP 诱导的小鼠血小板聚集[2]。
Cyproheptadine hydrochloride (10 nM) 能够在体外抑制血小板中 15 μM 血清素增强 adp (1μM) 诱导的酪氨酸磷酸化<[2]。
Cyproheptadine hydrochloride 抑制人血小板 PS 暴露 (Annexin V)、P-选择素和 GPIIb-IIIa (PAC-1 结合) 体外激活[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cyproheptadine hydrochloride 相关抗体:

体内研究
(In Vivo)

Cyproheptadine hydrochloride (0.01-100 nM；1 minute) 在体外剂量依赖性地抑制血清素增强的 ADP 诱导的小鼠血小板聚集[2]。
Cyproheptadine hydrochloride (10 nM) 能够在体外抑制血小板中 15 μM 血清素增强 adp (1μM) 诱导的酪氨酸磷酸化<[2]。
Cyproheptadine hydrochloride 抑制人血小板 PS 暴露 (Annexin V)、P-选择素和 GPIIb-IIIa (PAC-1 结合) 体外激活[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (8-10 weeks old)[2]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection, daily, for 5 days
Result: Prolonged occlusion times and tail bleeding times in mice.
Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT05469165 Laval University|Canadian Institutes of Health Research (CIHR)
Ischemic Mitral Regurgitation
2023-06-20 PHASE2
NCT01940978 Douglas Sears|
ADHD|Attention Deficit Hyperactivity Disorder|Attention Deficit Disorder With Hyperactivity|Mental Disorders Diagnosed in Childhood|Attention Deficit and Disruptive Behavior Disorders
2014-03 PHASE4
NCT01076283 Brown University|
Alcoholism
2009-12 PHASE2
分子量

323.86

同用名

盐酸赛庚啶; Cyproheptadine HCl

Formula

C21H22ClN

CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸赛庚啶

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

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