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野黄芩素(Scutellarein) 是天然黄酮类化合物，具有抗炎功效。
生物活性
Scutellarein is a natural flavonoid compound with anti-inflammatory effects.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
16.4 μM
Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay
[PMID: 24955889]
MV4-11 IC50
27.07 μM
Antiproliferation activity against human MV4-11 cells assessed as reduction in cell viability measured by Cell-titer-Glo assay
[PMID: 32088124]
RBL-2H3 IC50
67.2 μM
Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge
[PMID: 14510616]
体外研究
(In Vitro)
Scutellarein (0-200 μM，24 小时) 可抑制 LPS 激活的 RAW264.7 细胞中 NO 的产生，降低 iNOS 和 TNF-α 的 mRNA 表达水平[1]。
Scutellarein (0-50 μM，24 小时) 抑制 HT1080 细胞的增殖、迁移、集落形成并诱导细胞凋亡[3]。
Scutellarein (0-50 μM，24 小时) 抑制 HT1080 细胞中 MMP-2、-9 和 -14 的表达以及 NF-κB 的激活[3]。
Scutellarein 具有 DPPH、ABTS+·、·OH 自由基清除活性 (IC50 分别为 16.84 μM、3.00 μM、0.31 mM)[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Scutellarein 相关抗体:
Src Antibody (YA061)
SRC1 Antibody (YA060)
Phospho-Src (Tyr419) Antibody (YA150)
FYN Antibody
Lck Antibody (YA712)
Lyn Antibody (YA707)
CSK Antibody (YA2742)
FYB Antibody (YA973)
FYB Antibody (YA974)
TAGLN/Transgelin Antibody (YA1206)
Yes1 Antibody (YA1897)
SHC Antibody (YA2394)
Phospho-Src (Tyr530) Antibody (YA2656)
PELP1 Antibody (YA2962)
Tyrosine Protein Kinase HCK Antibody (YA2963)
体内研究
(In Vivo)
Scutellarein (50 mg/kg，饮食中，16 周) 在 HFD 小鼠中显示出抗肥胖作用，并显示出降脂和肝脏保护作用[2]。
Scutellarein (50 和 500 mg/kg) 可抑制小鼠 HT108 异种移植模型中的肿瘤生长[3]。
Scutellarein (0-1.40 mmol/kg，口服) 可改善神经元损伤，并保护大鼠免受脑缺血[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD mice[2]
Dosage: 50 mg/kg
Administration: in diet, 16 weeks
Result: Reduced lipid accumulation and levels of inflammatory factors in the liver.
Reduced the Body Weight.
分子量
286.24

同用名
野黄芩素; 6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone

Formula
C15H10O6

CAS 号
529-53-3

性状
固体

颜色
Light yellow to yellow

中文名称
野黄芩素；金黄紫碱；黄岑配基；高黄芩素；野黄芩黄素

结构分类
FlavonoidsFlavones PhenolsPolyphenols
初始来源
植物豆科蒺藜苜蓿 植物唇形科
运输条件
Room temperature in continental US; may vary elsewhere.

储存方式
4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)