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Maxpar Perm-S Buffer is optimized for permeabilization of cells following cell fixation with the Maxpar Fix I Buffer when performing intracellular staining of antigens located in the cytoplasm and secretory pathway, including cytokines, chemokines and growth factors. The Maxpar Perm-S Buffer is formulated to provide the best possible signal-to-noise ratio for antigen detection by mass cytometry.