2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) 是一种棕榈酰化抑制剂，靶向 DHHC (Asp-His-His-Cys) 蛋白棕榈酰转移酶。2-Bromohexadecanoic acid 抑制 GSDME-C 的棕榈酰化，抑制 BAK/BAX-Caspase 3-GSDME 通路介导的焦亡 (pyroptosis)。
生物活性
2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-Bromohexadecanoic acid inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis[1].

体外研究
(In Vitro)
棕榈酰化促进 GSDME-N 在切割后释放 GSDME-C，2-BP 抑制棕榈酰化过程，而抑制 GSDME-C 的修饰，增加了 GSDME-C 和 GSDME-N 之间的相互作用。2-BP 抑制 TNFa+CHX 诱导的细胞凋亡，但不抑制细胞总死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2-Bromohexadecanoic acid 相关抗体:
GSDME Antibody (YA398)
分子量
335.32

同用名
2-Bromopalmitic acid; 2-Bromopalmitate

Formula
C16H31BrO2

CAS 号
18263-25-7

性状
固体

颜色
White to yellow

中文名称
2-溴十六烷酸

运输条件
Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验：