搜索

购物车()
首页> 生物试剂


TLR2 Monoclonal Antibody
  • 商城价格 登录后可查看价格
  • 货号 YP-mAb-12943
  • 品牌 upingbio ( 经销商 )
  • CAS号
  • 规格/包装 53ul
  • 单位 支
  • 储存条件
  • 现货状态 三个工作日
  • 数量

    - +

    成功收藏产品
  • 立即购买
登录后可见商家信息
热门推荐
商家描述 产品评价(0)
Catalog No
YP-mAb-12943
Isotype
IgG
Reactivity
Human;Rat;Mouse;
Applications
WB
Gene Name
TLR2
Protein Name
Toll-like receptor 2
Immunogen
Purified recombinant fragment of human TLR2 expressed in E. Coli.
Specificity
TLR2 Monoclonal Antibody detects endogenous levels of TLR2 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Source
Monoclonal, Mouse
Purification
Affinity purification
Dilution
Western Blot: 1/500 - 1/2000.
Concentration
1 mg/ml
Purity
≥90%
Storage Stability
-20°C/1 year
Synonyms
TLR2; TIL4; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD
antigen CD282
Observed Band
90kD
Cell Pathway
Membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle,
phagosome membrane ; Single-pass type I membrane protein . Membrane raft .
Does not reside in lipid rafts before stimulation but accumulates increasingly in the
raft upon the presence of the microbial ligand. In response to diacylated
lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment
determines the intracellular targeting to the Golgi apparatus. Triacylated
lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers. .
Tissue Specificity
Highly expressed in peripheral blood leukocytes, in particular in monocytes, in
bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver.
Levels are low in other tissues.
Function
function:Cooperates with LY96 to mediate the innate immune response to
bacterial lipoproteins and other microbial cell wall components. Cooperates with
TLR1 to mediate the innate immune response to bacterial lipoproteins or
lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation,
cytokine secretion and the inflammatory response. May also promote apoptosis in
response to lipoproteins. Recognizes mycoplasmal macrophage-activating
lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble
modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L)
cooperatively with TLR6.,polymorphism:Genetic variations in TLR2 are
associated with suceptibility to leprosy [MIM:246300]. Leprosy is a chronic
返回顶部