搜索

购物车()
首页> 生物试剂


ADL 08-0011 HCl
  • 商城价格 登录后可查看价格
  • 货号 T70267
  • 品牌 TargetMol ( 生产厂家 )
  • CAS号 170098-43-8
  • 规格/包装 10 mg
  • 单位 瓶
  • 储存条件 -20度
  • 现货状态 一个半月
  • 数量

    - +

    成功收藏产品
  • 立即购买
登录后可见商家信息
热门推荐
商家描述 商家资质信息 产品评价(0)
ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.
返回顶部