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LDN-193189 2HCl
  • 商城价格 登录后可查看价格
  • 货号 T35348
  • 品牌 TargetMol ( 生产厂家 )
  • CAS号 1435934-00-1
  • 规格/包装 1 mg
  • 单位 瓶
  • 储存条件 -20度
  • 现货状态 现货
  • 数量

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LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively. LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors ALK2 and ALK3 in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively, and was 200-fold more selective for BMP than for TGF-β.
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