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WHI-P97
  • 商城价格 登录后可查看价格
  • 货号 T4657
  • 品牌 TargetMol ( 生产厂家 )
  • CAS号 211555-05-4
  • 规格/包装 1 mg
  • 单位 瓶
  • 储存条件 -20度
  • 现货状态 现货
  • 数量

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WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal.
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