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ABT-724 trihydrochloride is a potent and highly selective agonist of dopamine D4 receptor with EC50 of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 and the ferret D4 receptor, respectively. ABT-724 trihydrochloride has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride is useful for the treatment of erectile dysfunction and has favorable side-effect profile.