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Y-27632
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  • 货号 HY-10583
  • 品牌 MCE ( 经销商 )
  • CAS号
  • 规格/包装 10mg
  • 单位 支
  • 储存条件
  • 现货状态 询货
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Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor (ROCK-I Ki=220 nM; ROCK-II Ki=300 nM). Y-27632 dihydrochloride shows antiepileptic effects[1][2][3][4].

IC50 & Target[1]

ROCK-I

220 nM (Ki)

ROCK-II

300 nM (Ki)

PKN

3.1 μM (Ki)

Citron kinase

5.3 μM (Ki)

PKCα

73 μM (Ki)

PKA

25 μM (Ki)

体外研究
(In Vitro)

Y-27632 dihydrochloride (1-5 μM；0-60 分钟) 促进脂肪组织来源的干细胞 (ADSCs) 的神经元分化[3]。
Y-27632 dihydrochloride (1-5 μM；0-60 分钟) 诱导 ADSCs 中 NSE、MAP-2 和巢蛋白的表达[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: Adipose tissue-derived stem cells (ADSCs)
Concentration: 20 μM
Incubation Time: 24 hours
Result: Resulted in the up-regulation of NSE, MAP-2 and nestin protein levels by 25.3, 3.1 and 2.5 fold, respectively, compared to control cells not treated by Y-27632.
体内研究
(In Vivo)

Y-27632 dihydrochloride (口服灌胃；30 mg/kg；每日一次；4 周) 预防二甲基亚硝胺诱导的大鼠肝纤维化[1]。
Y-27632 dihydrochloride (口服灌胃；5- 10 mg/kg；once) 对 PTZ 和 MES 诱发的癫痫有抗癫痫作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats injected with dimethylnitrosamine[1]
Dosage: 30 mg/kg
Administration: Oral gavage; 30 mg/kg; once daily; 4 weeks
Result: Decreased the occurrence of dimethylnitrosamine-induced hepatic fibrosis and reduced the collagen and hydroxyproline content and α-smooth muscle actin expression in the liver.
分子量

320.26

性状

固体

Formula

C14H23Cl2N3O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

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