背景信息
This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.

RRID
AB_2862657
基因ID
7249
Swiss Prot
P49815
别名
LAM; TSC4; PPP1R160; TSC2
研究领域
Epigenetics & Nuclear Signaling
表观遗传学与核信号
Translation Control
翻译调控
Regulation of eIF4 and p70 S6 Kinase
eIF4 和 p70 S6 激酶的调控
Protein phosphorylation
蛋白质磷酸化
Signal Transduction
信号转导
mTOR Signaling Pathway
mTOR信号通路
Signal Transduction
信号转导
MAPK-Erk Signaling Pathway
MAPK-Erk信号通路
Cell Biology & Developmental Biology
细胞生物学-发育生物学
Cell Cycle
细胞周期
Cell cycle inhibitors
细胞周期抑制因子
Endocrine & Metabolism
内分泌代谢
AMPK Signaling Pathway
AMPK信号通路
Endocrine & Metabolism
内分泌代谢
Insulin Receptor Signaling Pathway
胰岛素受体信号通路
Endocrine & Metabolism
内分泌代谢
Endocrine and metabolic diseases
内分泌和代谢疾病
Obesity
肥胖
Signal Transduction
信号转导
PI3K-Akt Signaling Pathway
PI3K-Akt信号通路
Akt downstream targets
Akt下游靶点
Cell Biology & Developmental Biology
细胞生物学-发育生物学
Autophagy
自噬
Regulator
调节因子