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catalytic activity:(S)-lactate + NAD(+) = pyruvate + NADH.,caution:The sequence
shown here is derived from an Ensembl automatic analysis pipeline and should be
considered as preliminary data.,disease:Defects in LDHA are a cause of
exertional myoglobinuria.,online information:Lactate dehydrogenase
entry,pathway:Fermentation; pyruvate fermentation to lactate; (S)-lactate from
pyruvate: step 1/1.,similarity:Belongs to the LDH/MDH
superfamily.,similarity:Belongs to the LDH/MDH superfamily. LDH
family.,subunit:Homotetramer.,
Background
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD
to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is
found predominantly in muscle tissue and belongs to the lactate dehydrogenase
family. Mutations in this gene have been linked to exertional myoglobinuria.
Multiple transcript variants encoding different isoforms have been found for this