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CD324, also known as epithelial cadherin (E-cadherin) or uvomorulin, is a member of the cadherin superfamily. E-cadherin is a calcium-dependent, transmembrane cell-cell adhesion glycoprotein composed of four extracellular cadherin repeats and a highly conserved cytoplasmic tail region. It functions as a cell adhesion molecule involved in development, bacterial pathogenesis and tumor invasion. E-cadherin is widely expressed in epithelial cells in the colon, uterus, liver, keratinocytes, brain, heart, muscle, kidney and pancreas as well as in erythroid cells.
