商品介绍

gene_symbol：beta Catenin
Synonyms：armadillo; CTNNB; MRD19
clone_name：OTI12H7
immunogen：Full length human recombinant protein of human CTNNB1 (NP_001895) produced in HEK293T cell.
predicted_size：85.3 kDa
background：The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG1
host：Mouse
applications：FC, IF, IHC, WB
Recommend Dilution：WB 1:1000~2000, IHC 1:150, IF 1:100, FLOW 1:100
reactivities：Human, Rat, Monkey, Mouse
storage：Store at -20°C as received.