商品介绍

gene_symbol：RANGAP1
Synonyms：Fug1; RANGAP; SD
clone_name：OTI1B4
immunogen：Full length human recombinant protein of human RANGAP1 (NP_002874) produced in HEK293T cell.
predicted_size：63.4 kDa
background：RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq]
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG2a
host：Mouse
applications：FC, IF, IHC, WB
Recommend Dilution：WB 1:1000~2000, IHC 1:50, IF 1:100, FLOW 1:100
reactivities：Human, Dog, Rat, Mouse
storage：Store at -20°C as received.