商品介绍

gene_symbol：TMS1
Synonyms：ASC; CARD5; TMS; TMS-1; TMS1
clone_name：OTI2A7
immunogen：Full length human recombinant protein of human PYCARD (NP_037390) produced in E.coli.
predicted_size：21.4 kDa
background：This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG1
host：Mouse
applications：FC, IHC, WB
Recommend Dilution：WB 1:500~2000, IHC 1:150, FLOW 1:100
reactivities：Human
storage：Store at -20°C as received.