商品介绍

gene_symbol：TRPM4
Synonyms：hTRPM4; LTrpC4; PFHB1B; TRPM4B
clone_name：OTI10H5
immunogen：Full length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell.
predicted_size：134.3 kDa
background：Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG1
host：Mouse
applications：IHC, WB
Recommend Dilution：WB 1:5000~10000, IHC 1:50
reactivities：Human, Dog, Monkey
storage：Store at -20°C as received.