商品介绍

gene_symbol：MEK2
Synonyms：CFC4; MAPKK2; MEK2; MKK2; PRKMK2
clone_name：OTI1A2
immunogen：Full length human recombinant protein of human MAP2K2(NP_109587) produced in HEK293T cell.
predicted_size：44.2 kDa
background：The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG2a
host：Mouse
applications：IF, IHC, WB
Recommend Dilution：WB 1:200~4000, IHC 1:150, IF 1:100
reactivities：Human, Dog, Rat, Monkey, Mouse
storage：Store at -20°C as received.