商品介绍

gene_symbol：CCM2
Synonyms：C7orf22; OSM; PP10187
clone_name：OTI2E4
immunogen：Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell.
predicted_size：48.7 kDa
background：This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG1
host：Mouse
applications：IF, IHC, WB
Recommend Dilution：WB 1:2000, IHC 1:150, IF 1:100
reactivities：Human, Mouse, Rat
storage：Store at -20°C as received.