商品介绍

gene_symbol：RUNX1T1
Synonyms：AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2
clone_name：OTI1H1
immunogen：Full length human recombinant protein of human RUNX1T1(NP_783553) produced in HEK293T cell.
predicted_size：63 kDa
background：This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG1
host：Mouse
applications：IF, WB
Recommend Dilution：WB 1:2000, IF 1:100
reactivities：Human, Mouse, Rat
storage：Store at -20°C as received.