商品介绍

gene_symbol：PDHA1
Synonyms：PDHA; PDHAD; PDHCE1A; PHE1A
clone_name：OTI2C10
immunogen：Full length human recombinant protein of human PDHA1 (NP_000275) produced in HEK293T cell.
predicted_size：40.2 kDa
background：The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG2b
host：Mouse
applications：FC, IF, WB
Recommend Dilution：WB 1:2000, IF 1:100, FLOW 1:100
reactivities：Human, Mouse, Rat
storage：Store at -20°C as received.