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gene_symbol:Tyrosinase
Synonyms:ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
clone_name:OTI1F3
immunogen:Human recombinant protein fragment corresponding to amino acids 19-320 of human TYR (NP_000363) produced in E.coli.
predicted_size:58.3 kDa
background:The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
buffer:PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification:Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype:IgG1
host:Mouse
applications:IHC, WB
Recommend Dilution:WB 1:2000, IHC 1:150
reactivities:Human, Mouse, Rat
storage:Store at -20°C as received.
gene_symbol:Tyrosinase
Synonyms:ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
clone_name:OTI1F3
immunogen:Human recombinant protein fragment corresponding to amino acids 19-320 of human TYR (NP_000363) produced in E.coli.
predicted_size:58.3 kDa
background:The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
buffer:PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification:Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype:IgG1
host:Mouse
applications:IHC, WB
Recommend Dilution:WB 1:2000, IHC 1:150
reactivities:Human, Mouse, Rat
storage:Store at -20°C as received.