商品介绍

gene_symbol：Amyloid Precursor Protein
Synonyms：AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
clone_name：OTI5F1
immunogen：Full length human recombinant protein of human APP (NP_000475) produced in HEK293T cell.
predicted_size：87.0 kDa
background：This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG2a
host：Mouse
applications：IF, WB
Recommend Dilution：WB 1:2000, IF 1:100
reactivities：Human, Mouse, Rat
storage：Store at -20°C as received.