商品介绍

gene_symbol：p53
Synonyms：BCC7; LFS1; P53; TRP53
clone_name：OTIpab 240
immunogen：Gel-purified p53-beta-galactosidase fusion protein containing murine p53 from aa 14-389 (derived from pSV53C cDNA clone).
predicted_size：
background：This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG1
host：Mouse
applications：IHC
Recommend Dilution：IHC 1:500
reactivities：Human
storage：Store at -20°C as received.