商品介绍

gene_symbol：GAD67
Synonyms：CPSQ1; DEE89; GAD; SCP
clone_name：OTI5D8
immunogen：Full-length protein expressed in 293T cell transfected with human GAD1 expression vector
predicted_size：66.9 kDa
background：This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG1
host：Mouse
applications：IHC, IP, WB
Recommend Dilution：WB: 1:200 - 1:1000, IHC: 1:50, IP: 4ug/mL
reactivities：Human, Mouse, Rat
storage：Store at -20°C as received.