商品介绍

gene_symbol：CTLA4
Synonyms：ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12
clone_name：OTI8F1
immunogen：Full length human recombinant protein of human CTLA4 (NP_001032720) produced in HEK293T cell.
predicted_size：15 kDa
background：This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG1
host：Mouse
applications：FC, WB
Recommend Dilution：WB 1:500
reactivities：Human
storage：Store at -20°C as received.