商品介绍

gene_symbol：Thymidylate Synthase
Synonyms：HST422; TMS; TS
clone_name：OTI10F12
immunogen：Full length human recombinant protein of human TYMS (NP_001062) produced in E.coli.
predicted_size：35.5 kDa
background：Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG2a
host：Mouse
applications：IHC, WB
Recommend Dilution：WB 1:2000, IHC 1:150
reactivities：Human, Mouse, Rat
storage：Store at -20°C as received.