商品介绍

gene_symbol：beta Catenin
Synonyms：armadillo; CTNNB; MRD19
clone_name：OTI1F3
immunogen：Human recombinant protein fragment corresponding to amino acids 531-781 of human beta-catenin (NP_001895) produced in E.coli.
predicted_size：85.3 kDa
background：The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG2a
host：Mouse
applications：IHC, WB
Recommend Dilution：WB 1:1000~2000, IHC 1:50
reactivities：Human, Dog, Monkey, Mouse, Rat
storage：Store at -20°C as received.