商品介绍

gene_symbol：CD45
Synonyms：B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
clone_name：OTI2F1
immunogen：Full length human recombinant protein of human PTPRC(NP_002829) produced in HEK293T cell.
predicted_size：147.1 kDa
background：The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
isotype：IgG1
host：Mouse
applications：FC, IHC, WB
Recommend Dilution：WB 1:200~8000, IHC 1:150, FLOW 1:100
reactivities：Human
storage：Store at -20°C as received.