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function:May play a role in hematopoietic differentiation or inflammation.,induction:Up-regulated by LPS, in some cancer cells such as promyelocytic leukemia cells (HL-60) or myelomonocytic leukemia cells (U-937).,similarity:Belongs to the cystatin family.,subcellular location:May be targeted through the Golgi via the secretory pathway.,tissue specificity:Expressed in heart, placenta, lung, liver, skeletal muscle and pancreas. Not expressed in brain. Barely expressed in tumor cell lines except for breast adenocarcinoma MCF-7 cells and U251 cells.,