alternative products:Experimental confirmation may be lacking for some isoforms,catalytic activity:Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.,cofactor:Binds 2 zinc ions per subunit. Required for NAALADase activity.,domain:The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.,enzyme regulation:The NAALADase activity is inhibited by beta-NAAG, quisqualic acid, 2-(phosphonomethyl) pentanedioic acid (PMPA) and EDTA. Activated by cobalt.,function:Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.,function:Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates

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