function:Mediates cellular binding of particles and immune complexes that have activated complement.,miscellaneous:This is the sequence of the F allotype of CR1.,online information:Blood group antigen gene mutation database,polymorphism:CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria.,similarity:Belongs to the receptors of complement activation (RCA) family.,similarity:Contains 30 Sushi (CCP/SCR) domains.,subunit:Monomer.,tissue specificity:Present on erythrocytes, leukocytes, glomerular podo

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