domain:The C2 domains are not involved in calcium-dependent phospholipid binding.,function:Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.,similarity:Belongs to the unc-13 family.,similarity:Contains 1 MHD1 (MUNC13 homology domain 1) domain.,similarity:Contains 1 MHD2 (MUNC13 homology domain 2) domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 3 C2 domains.,subcellular location:Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.

非质量问题不退换