catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium or manganese.,disease:Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.,disease:Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).,enzyme regulation:Activated by binding of a complex consisting of CAB39 and STRAD or CAB39 and ALS2CR2.,function:Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein ki

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