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catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:Ref.9 has crystallized PPM1K in the presence of magnesium ions. However, PubMed:17336929 reported that no activity toward p-nitrophenylphosphate was seen in the absence of manganese ions and magnesium could not subsitute for manganese.,cofactor:Binds 1 magnesium or manganese ion per subunit.,function:Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,