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catalytic activity:ISG15 C-terminal thiolester + H(2)O = ISG15 + a thiol.,catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.,similarity:Belongs to the peptidase C19 family.,