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catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates MKK3 (By similarity). Activates the p38 MAP kinase pathway through the specific activation of the upstream MKK3 kinase.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Self-associates. Interacts with MKK3.,tissue specificity:Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle.,