catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The C-terminal auto-inhibitory domain interferes with kinase activity. RHOA binding leads to a conformation change and activation of the kinase. Truncated ROCK1 is constitutively activated.,enzyme regulation:Activated by RHOA binding.,function:Protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Necessary for apoptotic membrane blebbing. Plays a role in smooth muscle contraction. Required for centromere positioning and centromere-dependent exit from mitosis.,miscellaneous:Inhibited by Y-27632.,PTM:Autophosphorylated on serine and threonine residues. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Cleaved by caspase-3 during ap

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