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function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 1 FBA (F-box associated) domain.,subunit:Directly interacts with SKP1A and CUL1.,tissue specificity:Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.,