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developmental stage:Expression increases in senescent cells.,function:Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence.,induction:By the anticancer drug fluorouracil (5FU).,miscellaneous:Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell senescence and nuclear DNA damage.,similarity:Belongs to the MGR2 family.,tissue specificity:Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line.,