disease:Defects in RNF139 are a cause of renal cell carcinoma (RCC) [MIM:144700]. A chromosomal aberration involving RNF139 is found in hereditary RCC. Translocation (3;8)(q14.2;q24.1) with FHIT. The result is RNF139 is found to be fused to FHIT and disrupted within the sterol-sensing domain. In contrast, the FHIT coding region is maintained and expressed. Sporadic RCC, where an acquired mutation in RNF139 results in the duplication of 12 nucleotides in the 5'-UTR, has also been identified.,domain:The RING-type zinc finger domain may be essential for ubiquitin ligase activity.,function:Potential tumor suppressor for renal cell carcinoma. Plays a role in mediating ubiquitination. May function as a signaling receptor.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with VHL.,tissue specificity:Highly expressed in testis, placenta and adrenal gland. Moderate expression in hea

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